Using Precision Medicine to Prevent and Treat Alzheimer’s

Can you give examples of common treatments and lifestyle changes that are part of your protocol?

It’s basically diet, exercise, sleep, dealing with stress, brain training, some targeted supplementation, detoxification if needed, and drugs that are appropriate. I’m not against drugs—I prescribed them for years and years as a neurologist—but what’s interesting is that the drugs work much better when they are used as part of an optimal protocol. Bioidentical hormone replacement is something that can be quite helpful.

We use a plant-rich mildly ketogenic diet. Ketosis has been one of the most powerful tools to use against cognitive decline, because ketone bodies provide the brain with an alternative fuel to glucose. Ten years before a diagnosis of Alzheimer’s, PET scans show that people have low glucose utilization in the temporal and parietal lobes of the brain. That is the signature of Alzheimer’s disease.

Twelve to sixteen hours of fasting can be helpful. Regular exercise with both aerobic and strength training will help improve ketosis, insulin sensitivity, blood oxygenation, and blood flow to the brain.

There’s evidence that your blood oxygenation at night correlates with the size of parts of your brain. If you’re sleeping at night with an oxygenation of 88 or 90 percent instead of 98 percent, you may have a smaller brain. You want to get oxygen levels to optimal by dealing with sleep apnea and circulation. There are ways to check your oxygen level at night. One device we recommend is the Beddr SleepTuner, and there are also the Apple Watch and the Fitbit.

For brain training, we recommend Brain HQ because there are data published on it.

And then supplements. Supplements have gotten a terrible name because some companies make ridiculous claims. We’re saying supplements are among the things you can do to optimize your biochemistry. For example, if you’ve got low magnesium, which many people with Alzheimer’s do, then you can take magnesium threonate.

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Actor Matthew McConaughey Calls Out The Left For The Awful Way They Treat Conservatives (VIDEO)

It’s so rare that someone in Hollywood defends conservatives, that it’s newsworthy when it happens.

During a recent video podcast, actor Matthew McConaughey called out the left for their mistreatment of conservatives and Trump supporters.

It’s not clear that McConaughey is a Trump supporter himself, but he is more open minded than most in his industry.

Breitbart News reports:

TRENDING: China Whistleblower with Royal Ancestry Steps Forward – Reveals Video, Photos of Alleged Chinese Counterfeit Ballot Printing Operations of US Ballots for MS, FL and NC

Matthew McConaughey Calls Out ‘Arrogant’ Far Left Who ‘Condescend and Patronize’ Conservatives

Oscar-winning actor Matthew McConaughey called out the “arrogant” individuals on the far-left who “condescend and patronize” conservatives.

“On the far left, there is a lot [of people] on that illiberal left that absolutely condescend, patronize, and are arrogant towards the other 50 percent,” said Matthew McConaughey in a recent interview with actor Russell Brand.

The Gentlemen and True Detective actor’s remarks were in response to Brand’s question about what he thinks of the “condemnation and criticism” made by people in the entertainment industry of “ordinary working people” who voted for President Donald Trump or supported Brexit…

“Look, on the other side, on the far left — there is a lot [of people] on that illiberal left that absolutely condescend, patronize, and are arrogant towards the other 50 percent,” McConaughey continued. “Many people, I’m sure you saw it, in our industry, when Trump was voted in four years ago, they were un denial that it was actually real Some of them were in absolute denial.”

Watch the video below:

Good for him.

It’s so refreshing to hear a sane voice in Hollywood.

Cross posted from American Lookout.

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Dining News

The New 20th Century Cafe Cookbook Is a Treat for Cake-Making Diehards

20th Century Cafe, that retro-fabulous corner bakery in Hayes Valley, is publishing its first and definitive cookbook today. The cafe is known for its old-world European pastries, inspired by the grand cafe tradition in Vienna, Budapest, and Prague. Baking at the 20th Century Cafe is not for the faint of heart. It’s an advanced baking book, from a professional pastry chef, assiduously detailing methods for assembling ten-layer tortes and stretching strudel. But for cake diehards, it’s a rare treat, digging into the details of sachertorte, dobos torta, and of course, honey cake, while presenting them all on gold-rimmed china and a silver stand.

Pastry chef, owner, and now author Michelle Polzine cuts a tall figure around town, already known and loved for her sharp spectacles and tart smirk. And if you thought she was a kick in the pants behind the bar at her charming cafe, that style also comes through on the page, with plenty of references to 1930s couture and Hollywood glamour, if perhaps an overabundance of exclamation points. She’s also joined by Jessica Battilana, an award-winning columnist for the SF Chronicle and veteran recipe tester, who will have quietly ensured that those cakes work for home cooks.

Honey cake
Aya Brackett


Aya Brackett

Chapters roll through fruit, custards, cakes, cookies, and strudel, a few savory additions, and jams and sauces. But fans will head straight for the cakes. The recipe for the iconic Russian honey cake includes instructions on how to burn honey, whip in dulce de leche, bake off ten layers, and elegantly stack them tall. Vienna’s sachertorte is chocolate cake royalty, while Hungarian dobos torta is crowned in caramel. There’s an entire chapter dedicated to strudel, for those up for the challenge of stretching dough thin enough to cover an entire tabletop, before tucking and rolling apples. As well as recipes for all of the cafe favorites, including the chewy sourdough bagels and ruffled potato pierogis.

These are not quick and easy recipes — many are multi-day projects. Polzine enthusiastically calls it “high-stakes baking,” and warns cooks to arm themselves with a kitchen scale and an instant-read thermometer, and be prepared to read through recipes a couple of times. But for the more ambitious home baker, they’re a serious treat: career-tested recipes from a delightful pastry chef, who specializes in a very particular old cake tradition.

Michelle Polzine

Michelle Polzine
Aya Brackett

Photographs are from Aya Brackett, the Oakland photographer (who incidentally happens to be part of the Rintaro restaurant family). The images capture big spreads of cakes and cookies, on gold-trimmed china and silver stands, as well as cakes and tarts mid-process, revealing the graphic designs of layers, lattices, and centrifugal strawberries spiraling on a tart. And of course, Polzine’s style serves up big personality, with her signature vintage dresses and cat-eye spectacles, as she pulls layer after layer out of an impossibly cute old stove, and stretches pages and pages of paper-thin pastry across the table.

Cover of the 20th Century Cafe Cookbook

Artisan Books

Baking at the 20th Century Cafe comes out today, October 20, and is available from Omnivore Books, Green Apple Books, the Booksmith, and everywhere else grand cookbooks are sold.

All photos excerpted from Baking at the 20th Century Cafe by Michelle Polzine (Artisan Books). Copyright © 2020. Photographs by Aya Brackett.

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Surgery May Help Treat Sleep Apnea

By Serena Gordon

HealthDay Reporter

TUESDAY, Sept. 8, 2020 (HealthDay News) — Continuous positive airway pressure (CPAP) may be the go-to treatment for sleep apnea, but many people struggle to use it every night. For those who cannot tolerate CPAP, new research finds that a combination of surgical techniques may bring relief.

The “multilevel” treatment includes removing the tonsils, repositioning the palate (roof of the mouth) and using radiofrequency to slightly reduce the size of the tongue. In combination, these procedures open up the airway and reduce breathing obstruction, the researchers said.

The study found that the multilevel surgery technique reduced the number of times people stopped breathing (apnea events) during sleep and improved daytime sleepiness. People also reported better quality of life after the treatment.

“Obstructive sleep apnea is common and many people cannot use the main treatments, like CPAP masks. Surgery is a valid option when an expert surgeon is involved, and it can improve outcomes,” said the study’s lead author, Dr. Stuart MacKay. He’s an honorary clinical professor of otolaryngology, head and neck surgery at University of Wollongong, in Australia.

The researchers said that nearly one billion people worldwide suffer from sleep apnea. The airway becomes blocked during sleep, and as a result people stop breathing for short periods of time, multiple times throughout the night. People with sleep apnea have a higher risk of daytime sleepiness, motor vehicle crashes, and heart disease and stroke.

CPAP does a good job at keeping your airway open as you sleep, but the treatment — including a mask and a long tube — can be hard to get used to. The study authors said only about half of people with sleep apnea try CPAP.

For the new study, the researchers recruited 102 overweight or obese people with sleep apnea from six clinical centers in Australia, who were in their 40s, on average. The goal was to see if surgery could help adults with moderate or severe obstructive sleep apnea who weren’t able to tolerate or adhere to CPAP devices.

Half of the volunteers were randomly assigned to receive the sleep apnea surgery, while the other 51 continued with medical treatment. Medical management consisted of encouraging weight loss, drinking less alcohol, changing sleep posture and medical treatment for nasal obstruction.


MacKay said the multilevel surgical technique is widely available in many parts of the world. For the patients in this study, surgeries were performed by seven experienced surgeons.

Six months after the surgical procedures, volunteers in the surgery group had about a 27% decrease in the number of apnea events at night. Those on medical treatment had just a 10% decrease.

People in the surgical group also had major improvements in levels of snoring and daytime sleepiness, as well as a boost to quality of life.

As with any surgical procedure, there are risks.

“The main risks of pain and bleeding are confined to the two weeks after surgery. Bleeding occurs in about one in every 25 patients. Long-term risks related to taste disturbance, feeling of sticking in the throat, swallow dysfunction are very rare, although they do occur transiently in some,” MacKay said.

Dr. Steven Feinsilver is director of the Center for Sleep Medicine at Lenox Hill Hospital in New York City. He said, “Sleep apnea is a very common disease, about as common as diabetes, and similar to diabetes is associated with increased risk for cardiovascular events, such as stroke and heart disease.”

He added that “CPAP works, but is a difficult treatment.”

Feinsilver said that surgery that could provide a permanent cure has long been the goal for treatment.

“This study shows that relatively minor surgery, performed in a standardized fashion by skilled surgeons, can significantly improve sleep apnea compared to ‘medical treatment’ (essentially no treatment),” he said.

But he noted that even though people reported improvement, their nighttime breathing wasn’t back in the normal range.

“This is certainly a major improvement, but it remains unclear whether outcomes (such as cardiovascular risk) will be significantly impacted,” Feinsilver said. Also, he suggested that this multilevel surgery may only be an option for a select group of patients.

The report was published online Sept. 4 in the Journal of the American Medical Association.

WebMD News from HealthDay


SOURCES: Stuart MacKay, MD, honorary clinical professor, otolaryngology, head and neck surgery, University of Wollongong, Australia; Steven Feinsilver, MD, director, Center for Sleep Medicine, Lenox Hill Hospital, New York City;Journal of the American Medical Association, Sept. 4, 2020, online

Copyright © 2013-2020 HealthDay. All rights reserved.

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Treat Yourself to Sephora’s Labor Day 2020 Deals

We love these products, and we hope you do too. E! has affiliate relationships, so we may get a small share of the revenue from your purchases. Items are sold by the retailer, not E!.

With the upcoming three day weekend, you have all the more time to shop, and Sephora has some great deals going on. You can find steep discounts on your favorite brands like Marc Jacobs, Too Faced and more right now.

Below, shop some of our favorite sale finds from Sephora, from perfumes to eyeshadows. You can also currently get free shipping on all orders using the code FREESHIP, plus extended returns.

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Taylor Swift’s Surprise Cameo in Selena Gomez’s Cooking Show Is the Sweetest Treat

What are friends for, if not to make surprise cameos in your new HBO Max series? 

The one and only Taylor Swift pops in to see what’s cooking with Selena Gomez on the latest episode of her at-home culinary showSelena + Chef. The pop star turned aspiring cook is getting a lesson from acclaimed chef Roy Choi when she FaceTimes Taylor to show off the fruits of her labor. 

“Dude, look,” Selena tells Taylor, “I wanted to show you.” 

The folklore singer responds, “Oh my god, what is that?” as Roy explains they’ve whipped up a Korean barbecue Texas breakfast taco. “If you don’t send me the recipe, we’re going to have words,” Taylor teases her longtime bestie. “I want to be served that.” 

Taylor adds, “I’m very jealous of your whole setup and the fact that you guys are cooking together is pretty great. I’m really envious.” (Same, TBH.)

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What is used to treat covid-19? Not even doctors are sure.

Today, Jeff is alive, one of millions of people who have recovered after being diagnosed with covid-19, the illness caused by the coronavirus. But if you ask his grateful family or even his doctors what kept him alive, the answer is unsettling.

“We don’t know, and they don’t really know either,” Marylu said.

Seven months into the pandemic, front-line doctors have in many cases become experts in treating covid-19. But they are experts without, for the most part, the most fundamental tool in medicine — solid evidence upon which to base their decisions.

Today, the vaccine race is on, but answers about treatments remain frustratingly elusive, with a handful of basic therapies supported by evidence, and a messy and imperfect scramble to extract information about what works from what has been given to thousands of patients. Therapeutic regimens vary from hospital to hospital, and much of what is offered is supported by hints and hunches — what official treatment guidelines refer to as a “knowledge gap.”

“There’s a lot of things about this pandemic that have been so challenging, and I just don’t think in the early days people really appreciated how important it was to set up rigorous clinical studies right away of treatments,” said Kevin Schulman, a professor of medicine at Stanford University School of Medicine. “We’re so focused on a vaccine, and hopefully they work. We’re a little less focused on drug trials and other treatments.”

Among other therapies, Jeff Seidel was given the anti-malarial drug hydroxychloroquine. It has since fallen out of vogue, in large part because of a big clinical trial in the United Kingdom that tested multiple drugs against placebos and found it did not work.

The National Institutes of Health is preparing to launch a large, randomized trial to formally test different doses of blood thinners, which have been widely used to treat blood clots caused by the virus. Blood plasma from people who have recovered has now been given to more than 60,000 covid-19 patients, but the evidence that it works is still only suggestive.

“It is unfortunate we don’t have the kinds of data we would like to have now,” said Anthony S. Fauci, director of the National Institute of Allergy and Infectious Diseases. “That emphasizes and underscores something I repetitively talk about: the importance of the placebo-controlled randomized trial. Because if that had been done, we would have the answer to that right now … we could have [had] that answer some time ago.”

Medicine in a war zone

Rock-solid medical evidence depends on clinical trials, human experiments in which patients receive the real drug or a placebo. A flip of the coin determines whether patients get the real thing, and neither they nor their doctor know who is on the drug. These human experiments are essential, because even drugs backed by the most sensible rationale and promising lab research are often foiled by the trickiness of human biology.

But the uneven use of evidence to inform medical practice has long been a fissure running down the middle of American medicine — and that has turned into a chasm during the urgency of the pandemic.

“The U.S., for better and worse, is an every-person-for-himself kind of place,” said Christopher P. Austin, director of the National Center for Advancing Translational Sciences, part of the National Institutes of Health, the nation’s biomedical research agency. “ ‘Don’t tell me what to do, I’ve got the greatest idea in the world.’ Scientific discovery relies on that. But it is, in a situation like this, it is a counter-current.”

In normal times, doctors debate the art and science of medicine, argue for and against rigid guidelines and constantly navigate the gaps between peer-reviewed findings and their own years of experience. In a pandemic, when overwhelmed doctors scramble to treat patients, exhaust intensive care unit beds and are forced to reuse basic protective equipment, organizing the complex trials needed to rigorously test treatments has been even harder.

“It’s really a reflection of our general approach to clinical research,” said Robert Califf, a former commissioner of the Food and Drug Administration. “The pandemic has really exposed all the weaknesses that we already knew were there.”

Jeanne Marrazzo, an infectious diseases specialist at the University of Alabama at Birmingham, oversaw testing of remdesivir, an antiviral drug tested in a randomized trial that has since been authorized and is one of the research success stories of the pandemic. She says hand-wringing about the lack of gold-standard evidence simply does not take into account the situation on the ground.

“I think of what my clinical research team went through to enroll people in that trial, and I thought my nurses were going to die. One of them got covid and got sick,” Marrazzo said. In those early days, it took so long to get coronavirus test results that it could take a full day to get a patient qualified and screened for the study.

“Imagine trying to do that on a daily basis, multiple patients, some of them facing intubation, none of them have their families” with them, Marrazzo said.

On top of that, President Trump, the media and even doctors have often pushed the idea that unproven treatments are extremely promising, making it harder to ask families to take a placebo.

Judith Aberg, chief of the division of infectious diseases at Mount Sinai Health System in New York who runs clinical trials, said she finds herself spanning an uneasy divide. Her health system set up randomized trials for some treatments, but not for others. That may have been a lost opportunity to gather precious data in the United States, but the chaos of delivering care in a pandemic made some medical ideals impossible.

“It’s not good science. But you’re talking about how many people died. There was one day our system had 84 deaths,” Aberg said. “And then you’re going to ask me to potentially put them on a placebo? It’s just really heart wrenching, talking with families, if your patients are able to communicate — and you’re dealing with all these deaths.”

But physicians’ decisions on how to use unproved treatments on dying patients reverberate: Doctors may never know why that individual patient recovered or got worse — but they also do not gain crucial knowledge about how to treat the next hundred, or thousand, patients.

“You can make an enormous contribution, if instead of just giving treatments, one was able to randomize. … Randomizing, versus just arbitrarily or willy-nilly giving out treatments, in hope that they might work, but no hope that you’ll ever know,” said Martin Landray, one of the leaders of the U.K. trial, called RECOVERY, that has enrolled more than 12,000 patients and provided practice-changing findings.

That trial has become the envy of many U.S. researchers, so far showing hydroxychloroquine does not work, a widely-used HIV combination drug also does not work and an inexpensive steroid called dexamethasone can save the lives of patients who require supplemental oxygen.

A treatment from medical history

The yellowish liquid transfused into Jeff Seidel’s body on April 12 has become emblematic of the divide over how to use medical evidence in a pandemic. The idea is simple: Blood plasma from recovered patients contains virus-fighting antibodies that, in theory, help other people thwart the virus. Though unproven against covid-19, such transfusions are supported by a clear medical rationale and a century-long history in medicine.

To those on the front lines, the effort to collect and give plasma during the pandemic is a rare success story, a grass-roots medical effort made possible by the volunteerism of donors. A small network of physicians came together to create a treatment option for patients and physicians with nothing else to offer, pushing against institutional and bureaucratic inertia.

Michael J. Joyner, a Mayo Clinic anesthesiologist who leads a program to provide expanded access to the plasma therapy that is sponsored by the FDA, said the first institutional approval he received was to treat 5,000 patients — and at the time, that seemed like a distant goal. Today, more than 64,000 people have received plasma, with no major safety issues. A promising new analysis, not yet peer-reviewed, found that people given plasma early were less likely to die than those who got it later and plasma with higher doses of antibodies appeared more beneficial, but could not prove the transfusion was the cause.

People such as Califf, the former FDA commissioner, point out that if only 1,000 of those people had been randomized into trials, we might know how it works. Instead, he and three other former commissioners wrote in The Washington Post, “we are not much closer to definitively answering those questions.” But Joyner warned against judging the pandemic with the benefit of hindsight.

“At the time, it was a widely accepted, efficacious therapeutic modality that got revivified at scale,” Joyner said. “The retrospectoscope is a wonderful tool in medicine, but please use a wide-angle retrospectoscope and wield it with full knowledge of what actually happened.”

Shmuel Shoham, an associate professor of medicine at Johns Hopkins University School of Medicine, is leading a randomized clinical trial of plasma for preventing disease in people who have had a high-risk exposure. He said the process of treating patients with the best available knowledge while also trying to collect data does not cause a conflict: It is more like wearing a belt and suspenders.

“Let’s do things that seem reasonable, and as more data is collected, we can learn lessons. It’s not traditionally the way medicine is done, but being in this hopefully once-in-a-lifetime situation has pushed us to do things that are different, and to take, with the acceptance of patients, risks we wouldn’t normally have taken,” Shoham said.

One of Jeff Seidel’s doctors in Wisconsin, anesthesiologist William Hartman, said that over time, his hospital system has learned to give plasma as early as possible — before patients are placed on ventilators. They learned this not by doing a randomized trial, but by collecting data on the people they treated and studying trends. Now, patients who are hospitalized are typically offered plasma right away.

Hartman acknowledged it is hard to separate out the effect of any one treatment because other factors could influence patients’ outcomes, such as the nursing care his hospital was able to deliver, because it was not overwhelmed by patients like many hospitals in New York.

“Not having a huge surge of patients, we can give very focused, one-on-one nursing care, attendants can be very involved,” Hartman said. “It’s a different level of care when there’s mass chaos, and … it is hard to weed that out.”

For individual patients, such discussions are abstractions. Marylu’s heart leaped when Jeff seemed to do better after receiving the plasma and he gave her the okay sign over FaceTime. It fell the next day, when he slid backward and the nurse said his prognosis was still a guessing game.

Months later, the Seidels are simply grateful to be back home. Jeff still gets winded but has been weaned from supplemental oxygen. He has spent the summer fishing and enjoying life again, able to hug his grandson.

Now, the Seidels are looking forward with trepidation once again. Doctors are only beginning to understand the long-term effects of the virus, and Jeff has a heart scan scheduled in October. When they hear people talk about how the virus is similar to the flu, they shake their heads.

“We lived it,” Marylu said. “It can affect you long-term. We worry about that, and we worry about what’s next.”

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Racial disparities seen in how doctors treat pain, even among children

In a national study that included almost a million emergency room visits, black children in severe pain from acute appendicitis had just one-fifth the odds of receiving opioid painkillers compared with white children, even after adjusting for other factors.

The disparity may reflect that doctors were less likely to trust their black patients, particularly because the study also showed no difference in the prescription of non-opioid painkillers by race. Another study confirmed that racial disparities in opioid prescription are greater in conditions with fewer objective findings, such as migraine or back pain, which depend on a patient’s own assessment, as opposed to say a bone fracture, which shows up on an X-ray.

But another study suggests that broader racist myths about black people and pain might also be at play here. During slavery times, violence against enslaved black people was justified by a supposed greater tolerance for pain, and a ludicrously false belief that they had thicker skin. The study, from 2016, found a third of 222 white medical students and residents surveyed held that false belief. And those respondents, the study found, were also less likely to perceive the intensity of black patients’ pain and recommend appropriate treatment.

Because the appraisal of pain remains entirely subjective, confined exclusively to the eye of the beholder, a doctor or nurse’s ability to accurately assess and respond to a patient’s suffering is heavily dependent on empathy, the process that allows us to understand and share another person’s emotional state. Empathy is seen as an evolutionarily promoted phenomenon: Watching someone else wince in pain after, say, they grab a hot pan, may help us not make the same mistake. Being sensitive to others’ feelings allows us to form cohesive societies. In fact, brain imaging studies show that there is considerable overlap in the brain circuits that feel one’s own pain and those that react to the pain of others.

This racial intergroup bias in empathy is ubiquitous, but researchers have performed small, carefully planned experiments showing that it is not insurmountable. Overcoming racial intergroup bias in empathy could be central not just to achieving equity in pain management, but throughout medical care and society at large.

Simply living together and interacting with people of other races is associated with increases in empathy. The longer Chinese immigrants to Australia had lived in their new country, the more they were in everyday contact with white Australians, the more empathy toward their pain they exhibited.

A key factor that mediates implicit bias is that people emphasize the differences between people from other races rather than what unites them. A process called individuation training nudges people to focus on other people as individuals and on their unique traits and characteristics rather than which group they belong to. In one experiment, focusing on how much pain people from other races were feeling rather than the color of their skin increased the empathetic response generated, eliminating intergroup bias.

Another reason driving bias is the feeling of otherness generated by groups different from one’s own. In this same experiment, a biased response to the pain of other races was eliminated when they were included as part of the individual’s team in a mock game.

Training physicians to be more empathetic, particularly toward people of other races, may be an effective tool at closing the racial gap in pain relief. An empathetic physician can have a real impact on their patients’ well-being. In one study of nearly 3,000 adult patients from 2017, patients with chronic pain who rated their doctors as more empathetic experienced greater pain relief.

Last year, a former associate dean of curriculum at the Perelman School of Medicine at University of Pennsylvania wrote an op-ed in the Wall Street Journal decrying that “at ‘woke’ medical schools, curricula are increasingly focused on social justice rather than treating illness.” However, as this current moment has made clear, medical schools need to be doing more to train their graduates in overcoming the medical consequences of social injustice and bias. Nowhere is this more apparent than how they treat the person in pain.

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How to Treat MTHFR, COMT and DNA Mutations

The Power of Epigenetics

I’ve always been fascinated by the ways our bodies want to be healthy, and I’ve spent most of my life learning how to help them get there. As an undergraduate, I studied cell and molecular biology. I then became a naturopathic physician—a science-based practitioner who relies on natural methods to restore balance and optimize health. As I worked with patients, I realized that I also needed to become a specialist in environmental medicine, discovering both how the chemicals in our environment undermine our health and what we can do to detoxify our bodies.

What made all my diverse studies come together was the field of epigenetics: the many, many factors that can influence how our genes are expressed. I had always understood how powerful genes can be. But wow, was I thrilled to discover that we don’t have to bow down and submit to our DNA. Instead, we can work with our genes to create optimal health and, in a way, not exacerbate genetic mutations inside our bodies—if only we know how.

One of the most important pieces of the genetic puzzle is a type of variation known as a SNP (pronounced “snip”), which is short for single-nucleotide polymorphism. So far, roughly ten million SNPs have been identified in the human genome, with each of us having over a million. Most of those SNPs don’t seem to affect us very much. Yes, they represent a slight variation or abnormality in various genes, but so far as we know, those variations don’t seem to make much difference in the way our bodies function.

Some SNPs, however, can make a huge difference in our health—and in our personality, as well. For example, SNPs in the MTHFR gene can create a whole host of health problems—everything from irritability and obsessiveness to birth defects and cancer can be a result of an MTHFR gene mutation. (Note that I said can. They don’t have to—that’s what this is all about!) SNPs in the COMT gene can lead to workaholism, sleep issues, PMS, problems with menopause, and again, cancer, along with boundless energy, enthusiasm, and good spirits. (Yes, many SNPs have an upside as well as a downside!)

Health issues that had puzzled my clients for years suddenly made sense when they discovered through our work together that their SNPs had at least partly created those issues. Problems that had seemed overwhelming—even dooming—became manageable as clients learned that they could use diet and lifestyle to reshape their genes’ behavior.

I experienced that kind of aha moment myself when I discovered that I have at least three significant SNPs. I finally understood something about why I’m so focused and determined—some might say obsessive! Remember the MTHFR symptoms I mentioned earlier? I also saw why I can suddenly become irritable at a moment’s notice, and why I react so intensely to certain chemicals and fumes. It was a relief to have this new understanding: things made sense to me in a way they never had before, plus I had some new solutions I could rely on. As you read this, you’ll have the chance to make the same kind of exciting discoveries about yourself.

Most important, learning about my SNPs helped me understand some of the misconceptions about methylation disorders better and empowered me to take charge of my health. Finally, I could support my body and brain with the diet and lifestyle that they needed. For the first time in my life, I felt like I was working at the top of my potential.

I wanted my patients to have the same experience—heck, I wanted everybody to hit that high. So I began to develop a program for cleaning up our “dirty genes”: what we should eat, which supplements could help, and how to create a “clean genes” lifestyle. I wanted us to be like that epigenetically supported mouse, glowing and healthy, no matter which genes life has dealt us. I knew that if I could just delve deeply enough, I’d find the answers.

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And now, ten years later, I’m proud to say that I have. Oh, there’s still a ton more I have to learn—the whole field of epigenetics is just getting started, and we’re making new discoveries every day. I spend a big portion of every week doing my own research, and another big chunk of time reading the studies that my colleagues turn out. It’s more than one person could ever keep up with—and that’s the good news. In another ten years, I’m fully confident, we’re going to have the power to take charge of our health in ways we can’t even imagine.

Are Your Dirty Genes Making You Sick?

You’ve probably heard that your genes affect how healthy you can be. Almost certainly, your doctor has told you that because of the conditions that run in your family, you may be vulnerable to heart disease, depression, anxiety, and/or other disorders.

Most of the time, this news makes people feel discouraged. “I’m scared,” they tell me. “My genes are a mess. I’ve just gotta make the best of it.”

No way!

After years of research in the new science of gene abnormalities and methylation disorders, and having successfully treated thousands of clients, including my family and myself, I’m offering you an exciting new approach: a proven method to clean up your genetic limitations and create a healthier, more vibrant you.

So let me say it loud and clear: Your genes are not your destiny! But perhaps you’ve been taught that they are. Perhaps, like most people, you’ve been told that you inherited a “master plan”—characteristics that are written in stone from the moment of your conception until the day you die. In this view, your genes are a stern committee of judges handing down a life sentence.

“Hmm,” your genes seem to say. “Let’s give this woman depression, which she gets from her mother. And let’s throw in some heart disease, which runs on her father’s side. How about adding in a shy, anxious personality, which she gets from her grandmother? We’re almost done, but let’s throw in one more ingredient—a mild case of ADHD, nothing clinical. But, like two of her uncles, she’s always going to have a hard time focusing. There—all done! Good luck, lady! Enjoy the destiny that we’ve written for you, because there is absolutely nothing you can do to change it!”

Pretty bleak, right? Luckily, it’s wrong. Far from being written in stone, your genetic destiny is more like a document written in the Cloud—you get to edit and revise it every moment of your life. Every time you drink a soda, barrel through on four hours of sleep, use a shampoo loaded with industrial chemicals, or hit a stress bomb at your job, you’re putting the negative part of the document in giant type. And every time you eat some organic leafy greens, get a good night’s sleep, use a chemical-free shampoo, laugh with friends, or do some yoga, you’re enlarging the positive part of the document while reducing the negative part—genetic mutations, specifically—to a font so small, it might as well not be there at all.

Your genes don’t lay down the law; they negotiate with you. They don’t even speak with a single voice. They’re a committee, and sometimes they disagree with each other.

Some of the folks on that committee are harsh. They’re constantly shouting, “Heart disease!” or “Depression!” or “Crippling lack of confidence!” And if you don’t know the right way to work with them, those loud, harsh voices might rule the day.

But—and here’s how this is going to change your life—if you do know how to work with your “gene committee,” you can produce a much better outcome. You can get those loud negative voices to tone it down or even shut up completely. At the same time, you can turn up the volume on the voices that are saying, “Balanced mood!” “Healthy heart!” and “Self-confidence!”

So get ready to clean your dirty genes, folks, because that’s exactly what you’re going to do. In the pages to come and in my book Dirty Genes, you’ll find out how to change your genes and make the most of your genetic inheritance, now and for the rest of your life.

Are Your Genes Dirty? Some Common Symptoms

+ Aching joints and/or muscles
+ Acid reflux/heartburn
+ Acne
+ Allergic reactions
+ Anger and aggression
+ Anxiety
+ Attention issues
+ Blood sugar spikes and crashes
+ Brain fog
+ Cold hands and feet
+ Constipation
+ Cravings, especially for carbs and sugar
+ Depression
+ Diarrhea
+ Edginess
+ Fatigue
+ Fibromyalgia
+ Food intolerance
+ Gallstones
+ Gas and bloating
+ Headache/migraine
+ Heart racing
+ Indigestion
+ Insomnia
+ Irritability
+ Itchy skin
+ Menopause/perimenopause symptoms
+ Mood swings
+ Nosebleeds
+ Obesity/weight gain
+ Obsessiveness
+ Overreactive startle reflex
+ PMS / difficult periods
+ Polycystic ovarian syndrome (PCOS)
+ Rosacea
+ Runny nose / congestion
+ Sweating
+ Unexplained symptoms—just “not feeling right”
+ Workaholism

What Your Doctor Won’t Tell You—But I Will

If you’ve had trouble with any of the symptoms I’ve just listed, your doctor might have told you that you’re not really sick. Or maybe you’ve been offered drugs to medicate the symptoms—antibiotics, painkillers, antacids, antidepressants, anti-anxiety medications—without much attention to the underlying issues that produce those symptoms of methylation disorders.

Or perhaps you’ve been one of the lucky ones. Perhaps you’ve found a naturopathic physician, functional/integrative MD, osteopath, nurse practitioner, nutritionist, chiropractor, or other health professional who has helped you restore health and wellness through diet, lifestyle, and other natural means. Even so, your treatment is incomplete if you haven’t learned about dirty genes, the root cause of many of the conditions you’re struggling with.

That’s because epigenetics—modifying genetic expression to improve your life and health—is a cutting-edge aspect of medicine that most practitioners don’t understand. I’m one of the few people who have figured out how to translate genetic research into concrete actions that will improve your health, which is why so many leading health-care specialists come to me for training and advice. That’s why I spend so much of my time lecturing and consulting with physicians and providers—conventional, natural, and otherwise—as well as reading other people’s studies, doing my own research, and helping others regain their health. As a result, the suggestions here are based on the very latest scientific material. Most health-care providers simply aren’t aware of this information, though I’d be willing to bet that in a few years, programs like the one in my book, including answers on how to change your genes, will be widespread, even standard.

Meanwhile, once you understand what makes your genes dirty and how to clean them up, you’ll feel better than you ever thought you could.

Your Dynamic Genes

Remember, every moment of every day, your genes are working on that document about your health. They can write it in a way you like or a way you don’t like—but they’re always writing. And whether you know it or not, so are you.

For example, your genes keep telling your body, “Rebuild your skin!” As you know if you exfoliate, your skin is constantly dying and being replaced. So every moment of every day, your genes are adding to the document, telling your body to get on with the repair.

What kind of document do you think they write if you eat a high-sugar diet, skimp on sleep, or stress yourself out for days on end? Hmm, maybe something like: “Please give this woman dull, lackluster skin with plenty of acne and maybe a touch of rosacea.” On the other hand, provide your genes with healthy fats, plenty of sleep, and time to chill, and you’re going to see a different document: “This one gets healthy, glowing skin that makes her look ten years younger!” Your genes won’t stop writing until the day you die. But what they write is up to you.

Likewise, your genes are constantly producing documents about your gut lining, which is repaired and rebuilt every seven days. If you eat right and live right, you’re going to get away from genetic mutations and have a great document: “Keep that guy’s gut strong and healthy!” If you mess up your genes with poor diet and lifestyle, your document probably says something like: “Since this man is giving me so much extra work to do, I can’t focus on repairing his gut lining. He’s also not providing me the tools I need. So give this man a weak gut lining—the kind that lets food leak through.” Watch out for all the weight gain, immune issues, and other problems that are likely to follow!

Now here’s my personal favorite: the memo about your mind. Those instructions involve neurotransmitters—biochemicals such as serotonin, dopamine, and norepinephrine that govern your thoughts, moods, and emotions. Your brain runs on thousands of biochemical reactions, and there are countless ways the process can go wrong. Your goal is to give your genes whatever they need to produce an uplifting memo: “Keep this person sharp, focused, calm, and full of energy during the day, and relaxed, calm, and ready to sleep at night.” The memo you don’t want mentions forgetfulness, depression, anxiety, irritability, insomnia, addictions, and brain fog.

So yes, your genes write your life memo. But what they write is largely up to you. Sound good? Then let’s get started.

How Gene Mutations Mess with Your Health

Most likely, neither you nor your doctor is used to thinking about your genes as an active, dynamic factor affecting your present-day health. Instead, your genes seem like an unchangeable, unavoidable set of hard-wired instructions passed on from your parents at the moment of conception.

I want you to shift that mindset. Instead of seeing your genetic inheritance as a fixed set of instructions from the past—instructions written on a stone tablet handed down from the ancestors—I want you to see your genes as active participants in your daily health. Right now, while you’re reading this, thousands of genes throughout your body are giving instructions—to your brain, digestive tract, skin, heart, liver, and many other aspects of your anatomy. Those genetic instructions shape every facet of your experience and your health, and your genes are handing them out every single second. With every breath you take, every object you touch, every thought you have, you give your genes instructions—and they respond, leading to epigenetic changes.

Let’s say you eat a big lunch—too big, more than your body can handle. Oops! Your genes are overloaded. They stagger under the burden of all that food. They tell your metabolism to slow way down. They have trouble methylating—a key process that facilitates at least two hundred functions in your body, from skin repair, digestion, and detoxification to mood balance and clear thought. Because of the challenge posed by that overly large meal, hundreds of instructions are being given differently—and badly. You might promise yourself to eat light that night to make up for it, and maybe you even will. But that won’t prevent the damage you inflicted at lunchtime, when you didn’t give your genes the conditions they needed to do their job.

Or let’s say you stayed up late last night, playing a video game or answering email or binge-watching your favorite show. Now the alarm is going off and you can barely drag yourself out of bed. “I’ll make up for it this weekend,” you promise yourself—and maybe you will. Meanwhile, though, your genes are living in the present, and they aren’t happy about the lack of sleep. They give instructions that alter your digestion, your mood, your metabolism, and your brain, so that right now—not when you were first born, but now—your health shifts and slips and declines a little bit.

Of course, if most of the time you’re eating well and sleeping deeply and limiting your toxic exposure and managing your stress, an occasional big meal or late night doesn’t make all that much difference. Sure, your genes alter their responses for a little while, but your body is strong and resilient, and it can handle the extra challenge. If one gene staggers, a second one steps up. If that second gene stumbles, a third one takes over. Your body has lots of built-in backups, which is terrific.

However, if you consistently give your genes poor working conditions, they’re going to consistently hand out poor instructions and may result in methylation disorders in the process. Why? Because each backup gene is going to push on the next backup gene, one after the other after the other, and before you know it, too many of your genes are struggling. Your health will suffer, and in way too many cases your doctor won’t be able to do much more than prescribe a few drugs to medicate your symptoms.

I want something better for you—a lot better. I want you to give your genes exactly what they need to hand out the instructions for perfect health. I want your first-line genes working optimally as often as possible, putting the least possible strain on your backups. I want all your genes cooperating smoothly to give you glowing skin and a healthy weight and tons of energy and a clear, sharp mind. I want you feeling calm and enthusiastic and ready to go, and I want you sleeping so deeply at night that you wake up each morning feeling terrific. If you want that for yourself, listen up: The way to get optimal health is by supporting your genes.

Two Types of Dirty Genes

You have two types of dirty genes—both of which can give you a host of symptoms and disorders.

Some Genes Are “Born Dirty”

The scientific name for a born-dirty gene is genetic polymorphism, which is a fancy way of saying “genetic variation” or “genetic mutations” in some cases. As we saw in the introduction, these genes are also called single-nucleotide polymorphisms, or SNPs—pronounced “snips.” These dirty genes—and each of us has several—can do a full-scale number on your body and your brain. They help determine whether you’re heavy or slim, sluggish or energized, depressed or optimistic, anxious or calm.

We have about twenty thousand genes in our body. There are more than 10 million known genetic polymorphisms (SNPs), and one person can have as many as 1.2 million of them. However, only about 40,000 are known to potentially alter your genetic function. We’re going to zero in on the key SNPs in the seven genes most likely to have the biggest impact on your health. I chose these Super Seven because each of them influences hundreds of other genes. If any of these seven genes are dirty, you can be sure they’re making your other genes dirty, too.

When my clients first discover that they were born with SNPs, many of them are upset. As Taylor said, “I feel like a mutant.” But in fact, we’re all mutants—that is, every one of us is loaded with SNPs. It’s just part of the magnificent variety of the human race—what enables each of us to be unique.

The good news is that once you know which SNPs you have, your health issues start to make a lot more sense—and your emotional issues do, too. If you suffer from migraines, can’t seem to fall asleep at night, or struggle with a hair-trigger temper, SNPs may be at the root of your problem and hasten the development of methylation disorders. SNPs also contribute to anxiety, depression, irritability, workaholism, obsessiveness, difficulty paying attention, trouble winding down, and a whole bunch of other things that you might never have realized had a genetic and biochemical basis. SNPs also contribute to various strengths, such as boundless energy, good spirits, enthusiasm, dedication, determination, and laser-sharp focus.

The really good news is that you get to work with your SNPs, turning up the volume on your strengths and turning down the volume on your weak points. Through the Clean Genes Protocol, you can alter your lifestyle, diet, and environment to maximize the positives and mute the negatives, so that what you once thought was “normal” for you may be nothing of the kind. How awesome is that?

Some Genes Just “Act Dirty”

Sometimes a gene without a SNP creates problems for you anyway. That might be because your genes aren’t getting the nutrients, lifestyle, or environment that they need to function at their best—too few vitamins, too little sleep, too many chemicals, too much stress. A better diet and lifestyle might inspire your genes to behave differently.

The scientific name for this is genetic expression: the way your genes express themselves in response to your environment, diet, lifestyle, and mindset. Depending on which of your genes are expressed, and how, you can be healthy, energized, and glowing. Alternatively, you might be loaded down with a whole slew of symptoms: obesity, anxiety, depression, acne, headaches, fatigue, achy joints, poor digestion. If your genes act dirty enough, you might even face such serious conditions as autoimmune disorders, diabetes, heart disease, cancer and other forms of genetic mutations. Once again, your Clean Genes Protocol comes to the rescue. If you give your genes the diet and lifestyle that they need, they’ll act clean instead of dirty, and you can optimize your health, your mental outlook, and your life.

Meet Your Dirty Genes

Here are the seven genes—I call them the Super Seven—that we target with the Clean Genes Protocol. I chose them because they’re extremely common, have been well researched, and have the most far-reaching effects on your body. If these guys are dirty—whether born dirty or just acting dirty—the rest of your genes will be gunked up, too. Some genetic mutations are hard to scrub. Not these seven. They are easily cleaned up through diet and lifestyle changes. Being born with dirty genes has an upside as well as a downside.

Born-dirty genes might put you at risk for some nasty health challenges— but they also help to shape your personality, activating strengths as well as weaknesses. Your goal is to work with diet, chemical exposure, and lifestyle to maximize the benefits while minimizing the drawbacks.

1. MTHFR, the methylation master gene

This gene initiates your ability to methylate, a key process that affects your stress response, inflammation, brain chemistry, energy production, immune response, detoxification, antioxidant production, cell repair, and genetic expression, which, if not taken care properly, could lead to methylation disorders.

When MTHFR is born dirty:

+ Strengths: intensity, alertness, productivity, focus, improved DNA repair, decreased risk of colon cancer

+ Weaknesses: depression, anxiety, autoimmunity, migraines, increased risk of stomach cancer, autism, pregnancy complications, Down syndrome, birth defects, and cardiovascular conditions such as heart attack, stroke, and thrombosis

2. COMT, the gene whose SNPs help determine whether you’re focused and buoyant, or laid-back and calm

COMT and its SNPs have powerful effects on mood, focus, and how your body handles estrogen, a key factor in the menstrual cycle, in fibroids, in some estrogen-sensitive cancers and other genetic mutations.

When COMT is born dirty:

+ Strengths: focus, tons of energy and alertness, good spirits, glowing skin

+ Weaknesses: irritability, insomnia, anxiety, fibroids, increased risk of estrogen-sensitive cancers, test anxiety, neurological disorders, migraines, PMS, impatience, vulnerability to addictions

3. DAO, the gene whose SNPs can make you super sensitive to certain foods and chemicals

When this gene is dirty, aside from the development of methylation disorders, it affects your response to the histamine that lurks in various foods and beverages and that’s also produced by some gut bacteria, affecting your likelihood of food sensitivities and allergic reactions.

When DAO is born dirty:

+ Strengths: immediate awareness of allergens and trigger foods (so you can get them out of your diet before they cause serious long-term problems)

+ Weaknesses: food sensitivities, pregnancy complications, leaky gut syndrome, allergic reactions, the risk of more serious conditions such as autoimmunity

4. MAOA, the gene that affects mood swings and carb cravings

This gene helps govern your levels of dopamine, norepinephrine, and serotonin: key brain chemicals that affect mood, alertness, energy, vulnerability to addictions, self-confidence, and sleep.

When MAOA is born dirty:

+ Strengths: energy, self-confidence, focus, “highs” of productivity and joy

+ Weaknesses: mood swings, carb cravings, irritability, headaches, insomnia, addictions

5. GST/GPX, the gene(s) that can create detox dilemmas

A dirty GST or GPX affects your body’s ability to rid itself of chemicals.

When GST/GPX is born dirty:

+ Strengths: immediate awareness of potentially harmful chemicals (before they have the chance to make you really sick), improved response to chemotherapy

+ Weaknesses: supersensitivity to potentially harmful chemicals (with responses ranging from mild symptoms to serious autoimmune disorders and cancers), increased DNA damage (which increases the risk of cancer)

6. NOS3, the gene that can create heart issues

NOS3 affects your production of nitric oxide, which is a major factor in heart health, affecting such processes as blood flow and blood vessel formation.

When NOS3 is born dirty:

+ Strengths: decreased blood vessel formation (angiogenesis) during cancer, which reduces the growth of cancer

+ Weaknesses: headaches, high blood pressure, vulnerability to heart disease and heart attack, dementia

7. PEMT, the gene that supports your cell membranes and liver

This gene affects your body’s ability to produce phosphatidylcholine, an essential compound that you need to maintain cell membranes, bile flow, muscle health, and brain development.

When PEMT is born dirty:

+ Strengths: more support for methylation, better response to chemotherapy

+ Weaknesses: gallbladder disorders, small intestine bacterial overgrowth (SIBO), pregnancy complications, cell membrane weakness, muscle pain

What Makes Your Genes Act Dirty?

Even if you don’t have a SNP in any of your seven key genes, you might still be gunking up those genes with the wrong diet and lifestyle, which are two of the main factors that fuel genetic mutations. As a result, they can’t do the jobs you desperately need them to do—metabolize nutrients, balance your brain chemistry, repair damaged cells, and a hundred and one other tasks. What happens? You gain weight, feel sluggish, get depressed, become anxious, lose your ability to focus, develop acne, get headaches… the dirty list goes on and on.

If you’re taking antacids, for example, you’re messing with many major genes, including MTHFR, MAOA, and DAO. If you’re taking metformin, a common medication for diabetes, you’re disrupting the function of your MAOA and DAO. Birth-control pills, hormone replacement therapy, and even bioidentical hormones can strain your MTHFR and COMT.

Even if you’re not taking medications, your genetic expression can be disrupted by poor diet, lack of exercise, too much exercise, not enough sleep, environmental toxins, and plain old everyday stress—and those are just the most common problems. Long story short, there’s a whole laundry list of factors that might be dirtying up your genes—and your doctor probably has no idea.

To make matters worse, every additional factor that makes your genes dirty changes the whole picture and may even cause you severe forms of methylation disorders. So if you’re only eating too much sugar, that’s one problem. But if you’re also eating too many carbs, now you have two problems—and a much wider and more complex effect. If, in addition, you’re not getting good sleep, you’ve just created more damage. That plus stress—even more! Pretty soon, you’ve generated a cumulative effect that makes the whole problem even worse. Instead of 1 + 1 + 1 + 1 = 4, you get 1 + 1 + 1 + 1 = 50.

Why? Because all your genes interact with one another. When one gene gets dirty, it doesn’t work properly, so several more genes step up to help—and now suddenly they get dirty, too. Your body isn’t a set of discrete compartments that each work separately. It’s one amazing interactive system in which problems spread and multiply with amazing speed. The good news is that health can also spread and multiply in amazing ways. When you clean up your dirty DNA mutations, you start feeling terrific in ways you never even imagined. Your mood improves—and that chronic muscle pain you’ve been working through stops aching. Your brain fog clears—and you’ve got tons more energy. Your allergy symptoms disappear—and you begin to lose some weight.

This is why I’m so eager for you to clean up your genes so you can avoid genetic mutations. If your dirty genes were born clean but became dirty, cleaning them up gives you a tremendous boost. And if some of your genes were born dirty, giving them the support they need can make a world of difference.

What Dirties Up Your Genes?


+ Too many carbs

+ Too much sugar

+ Too much protein

+ Not enough protein

+ Not enough healthy fat

+ A shortage of nutrients that your genes need to work properly, such as B vitamins, vitamin C, vitamin D, copper, and zinc


+ Sedentary lifestyle

+ Overtraining

+ Electrolyte deficiency

+ Dehydration


+ Not enough deep, restorative sleep

+ Going to bed late, getting up late

+ Irregular sleep patterns

Environmental Toxins

+ “Dirty” food

+ “Dirty” water

+ “Dirty” air—including indoor air

+ “Dirty” products: sprays, cleaners, cosmetics, paints, pesticides, herbicides


+ Physical stress: long-term illness, chronic infections, food intolerance/allergies, insufficient sleep

+ Psychological stress: issues at work, at home, with your loved ones, with life

The Clean Genes Protocol: How to Change Your DNA

Following is your Clean Genes Protocol—a lifelong program to keep your genes clean and avoid bad genetic change as you optimize your health.

Although you may periodically add in Spot Cleaning from the second step of the program, which is outlined in my book, this is the approach to diet and lifestyle that will best support your genes for the rest of your life. Here the Clean Genes Protocol is outlined in broad brush strokes, as an introduction. Fear not, though: my book Dirty Genes addresses all the components—diet, exercise, and so on—in greater detail.


+ Eat appropriate amounts of protein and healthy fat.

+ Make sure to get all the nutrients that your genes need to work properly, such as B vitamins, vitamin C, copper, and zinc.

+ Cut out cow’s milk dairy, gluten, excess carbs, and white sugar.

+ Avoid foods high in pesticides, herbicides, preservatives, and/or artificial ingredients.

+ Avoid fermented foods, leftovers, or food that’s likely to contain excess bacteria if you find they trigger symptoms.

+ Avoid foods that are high in histamines: wine, some types of cheese, and smoked and/or preserved meat and fish, if you’re particularly susceptible.

+ Eat in moderation: stop eating when you’re 80 percent full.

+ Avoid snacks and late-night meals.


+ Get the right amount of exercise for your body—not too much and not too little.

+ Exercise when you’re rested and only until you’re pleasantly tired. Don’t exhaust yourself, and don’t force it.

+ Exercise when it doesn’t negatively impact your sleep. Don’t skimp on sleep to exercise; don’t exercise later in the evening if it keeps you from falling asleep.


+ Make trying for deep, restful sleep a priority.

+ Consistently match your sleep schedule to nature’s circadian rhythms: asleep by 10:30 p.m., awake seven to eight hours later.

+ Avoid electronic screens in the hour before bed.

+ Block out or turn off artificial lights. Natural moonlight is great.

Environmental Toxins

+ Eat organic food or at least avoid the “dirtiest” conventional foods.

+ Filter the water you use for drinking, cooking, and bathing.

+ Avoid the use of household and garden chemicals.

+ Avoid all plastic containers for your food and water, especially BPA plastic and especially in the microwave. Ideally, store and cook foods only in glass or stainless steel.

+ Follow guidelines to keep indoor air clean, bearing in mind that indoor air is often more toxic than the air outdoors.


+ Attend to sources of physical stress: long-term illness, chronic infections, food intolerances/allergies, insufficient sleep.

+ Reduce and relieve psychological stress: issues at work, at home, with your loved ones, with life.

Profiles and Personalities

Any one gene is just a single factor in your genetic profile—let alone in your entire personality. But to give you some idea of how your genetic profile might help shape your temperament, here are some quick personality sketches that I’ve observed in conjunction with the seven key genes when they’re dirty:


Among the many MTHFR symptoms are the changes in one’s mood. Some days you’re blue and depressed, while other days you’re anxious. On good days, your focus is great and you get stuff done. On bad days, you have performance anxiety, a hair-trigger temper, and/or headaches—or maybe you just feel grumpy. After eating a salad you tend to feel great, but you’ve never paid attention to that because, after all, it’s just a salad.

COMT (Slow)

Man, you’re on fire! ADHD?—not in this house. You’re cranking away on several projects and already eager for the next one or five. As you lie down to sleep, you’re still cranking away. After tossing and turning, you finally doze off, dreaming of tomorrow’s tasks. Tomorrow arrives. Coffee is needed. Once again, you’re off and running. You put pressure on yourself, and if you’re not accomplishing what you need to, anxiety sets in, so you focus harder to get everything done. And you do get it done. Your colleague makes fun of you for working overtime on a particular project, and you snap at her. As usual, you’re quick to be irritated. In addition, sometimes you have an extreme sensitivity to pain and can be plagued with headaches.

COMT (Fast)

Look at that blinking light! Did you see that dog over there? Man, I wish I could read a book, but I just can’t focus. You’re always jumping from one task to another, and it’s hard to get much done. Friends have suggested that you might have ADHD. You also love shopping and buying new things! The problem is, you feel great buying them, but the next day the “shopping high” wears off, and you find that you need to buy something else or you start feeling blue. It’s getting expensive and time-consuming. Oh—and hugs! They’re awesome! The more hugs you get, the better you feel.


You are so tired of not knowing what you can and can’t eat. One meal you’re good, and the next you feel awful: throbbing head, irritable mood, sweaty body, racing heart, itchy skin, bleeding nose. Perhaps you’ve even spent a ton of money on food allergy testing—and found nothing! So frustrating. You keep limiting your foods one by one in hopes of identifying the culprit, but it’s a never-ending battle.


Ever since you figured out that chemicals and smells make you feel sick, you’ve been on a mission to get rid of such stuff from your home. That neighbor of yours is using scented dryer sheets—again! Those give you a headache within seconds. Your friends wonder why you’re such a clean freak. But you know that you’re tuned in and sensitive to these things because you have to be.

MAOA (Fast)

Carbs. CARBS! Pleeease, get me some of those! Your grocery cart looks like you work for the grain and chocolate industry! You feel so great eating carb-laden foods. You know you shouldn’t, but when you don’t, you feel blue. The problem is, eating carbs picks you up only for a moment or two; then you crash. So what do you do then? You eat more carbs. You try diet after diet, but they just make you feel depressed. You’re sick of gaining weight, but you feel stuck in that pattern. You don’t want to be on antidepressants, but you feel like you can’t keep going this way.

MAOA (Slow)

You’re easily startled and quick to become anxious or irritated. You can become aggressive and later feel bad for overreacting. You just can’t seem to help it. You always have to watch out for headaches, especially when you eat cheese or chocolate and drink wine. Falling asleep at night is always tough, but once you do, at least you sleep soundly through the night.


You’re freaking out. Your dad, uncle, grandma, and grandpa all had significant heart problems when they were around fifty years old, and now you’re getting there. Your doctors check your heart and say it looks okay—but are they checking everything they need to, or are they missing something? Your hands and feet are constantly cold, but your doctors say that’s nothing to worry about. You need answers, because this family history is weighing on you.


Ever since you switched to a vegan or vegetarian diet, you’ve felt just a bit off. Your mind isn’t as sharp, you’re forgetting things, and you’ve got aches and pains all over your body. As an omnivore, you felt good overall, though you did have some aches and pains. Your liver felt heavy then, and it still does—just under your right-side ribcage. Fatty foods just don’t sit right with you either. Now your doctor has said that you have gallstones and need to have your gallbladder taken out. No! There must be a way to save it.

What’s Your Genetic Profile?

If you want to know your own genetic profile, there are a few ways to go about it. The most expensive route is to get yourself tested by a company like 23andMe or Genos Research. At that point, you’ll know exactly where all your SNPs are—but you won’t necessarily know what those results mean.

Another route is to invest four weeks in my book’s Clean Genes Protocol. Most people I know, including health professionals, get genetic testing results back and focus only on the genes. The problem is, that genetic report is a piece of paper showing your genetic susceptibility—not your genetic destiny! In other words, your genetic profile is not you.

Most of the folks who send away for genetic testing are unaware that a gene born clean can easily become dirty. When they read that their MTHFR is normal, they celebrate instead of realizing that—due to diet and lifestyle—it might in fact be super dirty.

Even if your MTHFR was born dirty or you are showing no symptoms of an MTHFR gene mutation, you don’t want to make the common mistake of thinking that you can target it with a magical methylfolate supplement or nutrition vitamin B12 supplement and all will be well. Many of the people who send away for their genetic profile end up following simplistic instructions for MTHFR treatment, thereby creating significant side effects and making themselves worse off than they were before.

Here’s the bottom line: the only way to truly help your dirty genes is by remaining on the Clean Genes Protocol, a lifelong approach to diet and lifestyle, including a specific MTHFR diet. That’s how I do it. That’s how my family does it. That’s how the doctors I’ve trained around the world encourage their patients to do it. The result? Healthier, happier lives. I’ll tell you what I tell all of them: there are no shortcuts. The tortoise always wins the race.

Because your genes can give you problems whether they’re born dirty or simply acting dirty, I want you to know how to keep all seven of these important genes clean and healthy, giving them all the support they need. Out of the roughly twenty thousand genes in your body, these seven are critical to optimal health, every day of your life.

When I say you’re going to scrub your dirty genes clean, I’m not saying that you’re going to change your basic personality or remove all medical risk. I’m saying that you’ll learn to work with your genes, giving them all the support they need. That way, you can celebrate your unique temperament—and safeguard your health from genetic mutations.

Every vehicle drives differently. By understanding your genetics, you gain the opportunity and ability to make choices that will give you a smooth and enjoyable ride throughout your life.

Excerpted with permission from Dirty Genes: A Breakthrough Program to Treat the Root Cause of Illness and Optimize Your Health by Dr. Ben Lynch. Available online at

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Breaking New

Lorna Breen, an ER doctor who continued to treat patients after she recovered from Covid-19 has died by suicide

Dr. Lorna Breen, 49, died a hero, said her father, Philip Breen.

“She was in the trenches,” he said. “She was a hero.”

Lorna Breen died Sunday morning by suicide in Charlottesville, Virginia, her father said.

Breen worked in the Columbia University Irving Medical Center and New York-Presbyterian hospital system.

‘Killed by the enemy on the front line,’ father says

“She went down in the trenches and was killed by the enemy on the front line,” Philip Breen said. “She loved New York and wouldn’t hear about living anywhere else. She loved her coworkers and did what she could for them.”

“I just want people to know how special she was,” he added.

Philip Breen is a retired trauma surgeon, and he and his daughter would speak frequently about work, he said.

Lorna Breen told her father that her colleagues were putting in 18-hour days and sleeping in hallways, and that ambulances couldn’t get in because it was so busy.

She worked in the emergency department and had been on the front lines for weeks, handling the onslaught of cases, her father said. New York City has been the US’ pandemic epicenter, recording nearly 300,000 cases and more than 22,000 deaths as of Tuesday morning.
Breen contracted Covid-19 and took a week and a half off to recover, but when she went back to work, she couldn’t last through a 12-hour shift, her father said. Still, she felt like she had to get back in there to help her colleagues.

Then, a doctor friend visited Breen at home and told her she should go home to Virginia, where most of her family is based, Philip Breen said. Some friends and relatives helped get her to Charlottesville.

She was hospitalized and treated for exhaustion

Lorna Breen soon was admitted to the hospital at the University of Virginia for exhaustion, her father said, adding that her mother is a doctor in the ward where she was treated.

After about a week, Lorna Breen left the hospital to stay with her mom, her father said. Then, last weekend, she went to stay with her sister, and that is where she died.

Officers responded Sunday to a call for medical assistance and identified the victim as Breen, the Charlottesville Police Department said in a news release. She was taken to University of Virginia Hospital for treatment and “later succumbed to self-inflicted injuries,” police said.

“Frontline healthcare professionals and first responders are not immune to the mental or physical effects of the current pandemic,” said Charlottesville Police Chief RaShall Brackney. “On a daily basis, these professionals operate under the most stressful of circumstances, and the Coronavirus has introduced additional stressors.”

“Words cannot convey the sense of loss we feel today,” the New York City hospitals where Breen worked said in a statement.

“Dr. Breen is a hero who brought the highest ideals of medicine to the challenging front lines of the emergency department,” they said. “Our focus today is to provide support to her family, friends, and colleagues as they cope with this news during what is already an extraordinarily difficult time.”

How to get help: In the US, call the National Suicide Prevention Lifeline at 1-800-273-8255. The International Association for Suicide Prevention and Befrienders Worldwide also can provide contact information for crisis centers around the world.

CNN’s Brian Vitagliano contributed to this report.

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